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K Darrell Berlin Selected Research

(((4- nitrophenyl)amino)(2,2,4,4- tetramethyl thiochroman-6-yl)amino) methane-1-thione

5/2019Synthesis and biological evaluation of SHetA2 (NSC-721689) analogs against the ovarian cancer cell line A2780.
10/2018Activity of oxygen-versus sulfur-containing analogs of the Flex-Het anticancer agent SHetA2.
1/2015Synthesis and evaluation of second generation Flex-Het scaffolds against the human ovarian cancer A2780 cell line.
6/2014SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres.
5/2009Development of flexible-heteroarotinoids for kidney cancer.
7/2008CAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction is a major component of SHetA2-induced apoptosis in lung cancer cells.
10/2007Heteroarotinoids with anti-cancer activity against ovarian cancer cells.
10/2005Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.
7/2003The synthetic heteroarotinoid SHetA2 induces apoptosis in squamous carcinoma cells through a receptor-independent and mitochondria-dependent pathway.

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K Darrell Berlin Research Topics

Disease

9Neoplasms (Cancer)
03/2016 - 07/2003
7Ovarian Neoplasms (Ovarian Cancer)
05/2019 - 02/2004
2Lung Neoplasms (Lung Cancer)
11/2008 - 07/2008
1Weight Loss (Weight Reduction)
05/2009
1Kidney Neoplasms (Kidney Cancer)
05/2009
1Tachycardia (Tachyarrhythmias)
09/2007
1Uterine Cervical Neoplasms (Cancer of the Cervix)
10/2005
1Squamous Cell Carcinoma of Head and Neck
07/2003
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
07/2003

Drug/Important Bio-Agent (IBA)

9(((4- nitrophenyl)amino)(2,2,4,4- tetramethyl thiochroman-6-yl)amino) methane-1-thioneIBA
05/2019 - 07/2003
4Proteins (Proteins, Gene)FDA Link
03/2016 - 07/2008
3RetinoidsIBA
07/2008 - 07/2003
2Biological ProductsIBA
05/2019 - 01/2015
2ThioureaIBA
10/2018 - 01/2015
2Urea (Carbamide)FDA LinkGeneric
10/2018 - 01/2015
2Pharmaceutical PreparationsIBA
03/2016 - 05/2009
2TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA
11/2008 - 07/2008
2Retinoic Acid Receptors (Retinoic Acid Receptor)IBA
10/2005 - 02/2004
2FenretinideIBA
10/2005 - 02/2004
1SulfurIBA
10/2018
1Benzene (Benzole)IBA
10/2018
1Oxygen (Dioxygen)IBA
10/2018
1ChromansIBA
10/2018
1CollagenIBA
06/2014
1Carrier Proteins (Binding Protein)IBA
06/2014
1mortalinIBA
06/2014
1Cadherins (E-Cadherin)IBA
05/2009
1Caspase 3 (Caspase-3)IBA
05/2009
1Messenger RNA (mRNA)IBA
05/2009
1SurvivinIBA
11/2008
1CCAAT-Enhancer-Binding ProteinsIBA
07/2008
1ThionesIBA
10/2007
1GLG-V 13IBA
09/2007
1Sotalol (Sotalol Hydrochloride)FDA LinkGeneric
09/2007
1Transcription Factors (Transcription Factor)IBA
10/2005
1Tretinoin (Retinoic Acid)FDA LinkGeneric
10/2005
1Retinoid X Receptors (Retinoid X Receptor)IBA
10/2005

Therapy/Procedure

1Microspheres (Microsphere)
06/2014
1Oral Administration
10/2005
1Therapeutics
07/2003
1Chemoprevention
07/2003